A potent antimalarial trichothecene from hyphomycete species

作者：Waterman Carrie; Calcul Laurent; Mutka Tina; Kyle Dennis E; Pearce Cedric J; Baker Bill J^*

来源：Tetrahedron Letters, 2014, 55(29): 3989-3991.

DOI：10.1016/j.tetlet.2014.05.056

• Hyphomycetes
• High-throughput screening
• Antimalarial
• Sesquiterpene
• Trichothecinol D

Antimalarial screening of diverse fungal samples resulted in the isolation and identification of a new sesquiterpene, trichothecinol D (1), which exhibited potent in vitro activity against Plasmodium falciparum with a 200-fold selectivity for parasite versus mammalian cytotoxicity. Trichothecinol D was obtained by bioassay-guided fractionation of two hyphomycete species. Its chemical characterization was performed by detailed NMR spectroscopy and high resolution mass spectrometry. The absolute configuration of trichothecinol D was determined by X-ray crystallography.

• 出版日期2014-7-16