Mechanisms of Bicarbonate Secretion: Lessons from the Airways

作者：Bridges Robert J^*

来源：Cold Spring Harbor Perspectives in Medicine, 2012, 2(8): a015016.

DOI：10.1101/cshperspect.a015016

Early studies showed that airway cells secrete HCO3- in response to cAMP-mediated agonists and HCO3- secretionwas impaired in cystic fibrosis (CF). Studies with Calu-3 cells, an airway serous model with high expression of CFTR, also showthe secretion of HCO3- when cells are stimulated with cAMP-mediated agonists. Activation of basolateral membrane hIK-1 K+ channels inhibits HCO3- secretion and stimulates Cl- secretion. CFTR mediates the exit of both HCO3- and Cl- across the apical membrane. Entry of HCO3- on a basolateral membrane NBC or Cl- on the NKCC determines which anion is secreted. Switching between these two secreted anions is determined by the activity of hIK-1 K+ channels.

• 出版日期2012-8