A conservation law for virus infection kinetics in vitro

作者:Kakizoe Yusuke; Morita Satoru; Nakaoka Shinji; Takeuchi Yasuhiro; Sato Kei; Miura Tomoyuki; Beauchemin Catherine A A; Iwami Shingo*
来源:Journal of Theoretical Biology, 2015, 376: 39-47.
DOI:10.1016/j.jtbi.2015.03.034

摘要

Conservation laws are among the most important properties of a physical system, but are not commonplace in biology. We derived a conservation law from the basic model for viral infections which consists in a small set of ordinary differential equations. We challenged the conservation law experimentally for the case of a virus infection in a cell culture. We found that the derived, conserved quantity remained almost constant throughout the infection period, implying that the derived conservation law holds in this biological system. We also suggest a potential use for the conservation law in evaluating the accuracy of experimental measurements.

  • 出版日期2015-7-7