MULTI-PLANAR DYNAMIC CONTRAST-ENHANCED ULTRASOUND ASSESSMENT OF BLOOD FLOW IN A RABBIT MODEL OF TESTICULAR TORSION

作者：Paltiel Harriet J^*; Estrada Carlos R Jr; Alomari Ahmad I; Stamoulis Catherine; Passerotti Carlo C; Meral F Can; Lee Richard S; Clement Gregory T

来源：Ultrasound in Medicine and Biology, 2014, 40(2): 361-370.

DOI：10.1016/j.ultrasmedbio.2013.08.017

• Blood flow
• Ultrasound
• Ultrasound contrast
• Radiolabeled microspheres
• Testicular torsion
• Experimental studies

To assess correlation between multi-planar, dynamic contrast-enhanced ultrasound (US) blood flow measurements and radiolabeled microsphere blood flow measurements, five groups of six rabbits underwent unilateral testicular torsion of 0 degrees, 180 degrees, 360 degrees, 540 degrees or 720 degrees. Five US measurements per testis (three transverse/two longitudinal) were obtained pre-operatively and immediately and 4 and 8 h post-operatively using linear transducers (7-4 MHz/center frequency 4.5 MHz/10 rabbits; 9-3 MHz/center frequency 5.5 MHz/20 rabbits). Bjorck's linear least-squares method fit the rise phase of mean pixel intensity over a 7-s period for each time curve. Slope of fit and intervention/control US pixel intensity ratios were calculated. Means of transverse, longitudinal and combined transverse/longitudinal US ratios as a function of torsion degree were compared with radiolabeled microsphere ratios using Pearson's correlation coefficient, rho. There was high correlation between the two sets of ratios (r >= 0.88, p <= 0.05), except for the transverse US ratio in the immediate post-operative period (rho = 0.79, p = 0.11). These results hold promise for future clinical applications. (E-mail: [e-mail].

• 出版日期2014-2