A Single Fixed-Dose Combination for All Patients Is Bad Medicine

作者:Spence J David*
来源:Canadian Journal of Cardiology, 2014, 30(5): 513-516.
DOI:10.1016/j.cjca.2014.01.018

摘要

It has been proposed that cardiovascular risk could be markedly reduced by prescribing a single daily pill to all patients at risk. This concept is bad medicine, because each constituent has problems, and the problems are different for each patient. A key principle of clinical pharmacology is individualization of therapy. Patients are not all the same, so a single polypill cannot work for all of them. For patients with resistant hypertension, at least 3 different versions would be needed for patients with different causes of hypertension, and even then not one pill would be suitable for all patients.

  • 出版日期2014-5