Advanced Lymphocyte-rich Classical Hodgkin Lymphoma Complicated with Fatal Hemophagocytic Syndrome

作者：Ichikawa Satoshi^*; Takahashi Taro; Katsushima Hiroki; Fukuhara Noriko; Ichinohasama Ryo; Harigae Hideo

来源：Internal Medicine, 2016, 55(2): 191-196.

DOI：10.2169/internalmedicine.55.5942

• lymphocyte-rich classical Hodgkin lymphoma
• hemophagocytic syndrome
• pulmonary Hodgkin lymphoma

Lymphocyte-rich classical Hodgkin lymphoma (LRCHL) is a rare subtype of Hodgkin lymphoma with a favorable prognosis, and an aggressive clinical course of LRCHL is uncommon. A 55-year-old man suffering from swelling in the left neck was diagnosed with LRCHL with extranodal lesions in the lung and bone marrow. Initially, he received standard ABVD chemotherapy; however, disease progression, accompanied by hemophagocytic syndrome (HPS), occurred during the second course of ABVD. He received two subsequent courses of intensive chemotherapy containing high-dose steroids, cyclophosphamide, and etoposide. Nevertheless, this therapy was only temporarily effective, and he died of due to an aggressive disease progression accompanied by uncontrollable HPS and severe coagulopathy.

• 出版日期2016