A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors

作者：Meng, Xian-Ze; Wu, Feng; Wei, Pin-Kang^*; Xiu, Li-Juan; Shi, Jun; Pang, Bin; Sun, Da-Zhi; Qin, Zhi-Feng; Huang, Yi; Lao, Lixing

来源：Evidence-Based Complementary and Alternative Medicine, 2012, 2012: 691258.

DOI：10.1155/2012/691258

• DSM-IV DISORDERS
• QUALITY-OF-LIFE
• MENTAL-HEALTH
• PSYCHIATRIC-DISORDERS
• MAJOR DEPRESSION
• CHRONIC PTSD
• FOLLOW-UP
• COMORBIDITY
• SYMPTOMS
• PREDICTORS

Introduction. Posttraumatic stress disorder (PTSD) is accompanied by poor general psychological status (GPS). In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD. Methods. A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula, Xiao-Tan-Jie-Yu-Fang (XTJYF), to placebo in 2008 Sichuan earthquake survivors with PTSD. Patients were randomized into XTJYF (n = 123) and placebo (n = 122) groups. Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R) and rates of response in the SCL global severity index (GSI) were the primary endpoints. A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints. Results and Discussion. Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices (P = 0.001 similar to 0.028). More patients in the XTJYF group reported "much improved" than the placebo group (P = 0.001). The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility (P = 0.001 similar to 0.036)), and in sleep quality score (P < 0.001). XTJYF produced no serious adverse events. These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD.

• 出版日期2012
• 单位中国人民解放军第二军医大学; 天津市中医药研究院附属医院