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摘要
Aim: The aim of this study was to investigate the relationships between 25-hydroxy-vitamin D (25(OH) D) and insulin resistance in obese adolescents with non-alcoholic fatty liver disease (NAFLD). Patients and methods: Eighty-seven obese adolescents (45 girls and 42 boys, mean age: 12.7 +/- 1.3 years, mean body mass index standard deviation score (BMI-SDS): 2.1 +/- 0.3) and 30 lean subjects (15 girls and 15 boys, mean age: 12.3 +/- 1.45 years, mean BMI-SDS: 0.5 +/- 0.7) were enrolled for the study. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver with high transaminases (NAFLD group and non-NAFLD group). Fasting blood samples were assayed for 25(OH) D, transaminases, glucose, and insulin levels. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR). Results: 25(OH) D measurements were decreased in both obese groups (NAFLD and non-NAFLD) in comparison with the lean group (29.5 +/- 18.4 vs. 41.0 +/- 17.9 vs. 48.1 +/- 22.2 ng/mL). However; the NAFLD group had significantly lower measurements of 25(OH) D than the non-NAFLD group (p < 0.001) and lean group (p < 0.001). 25(OH) D was negatively correlated with HOMA-IR (r = -0.158, p = 0.01) and with alanine aminotransferase (r = -0.794, p = 0.03) in the NAFLD obese group. There was no significant associations between fasting insulin, BMI-SDS and 25(OH) D in obese groups. Conclusion: We suggest that low 25(OH) D occurs commonly in obese adolescents with NAFLD and we demonstrated an association between insufficient vitamin D status and low insulin sensitivity in obese adolescents with NAFLD.
- 出版日期2013-8
