A sequence similar to bacterial transposable IS elements present in the 5 ' untranslated region of the bovine butanediol dehydrogenase cDNA

作者：Smania AM^*; Saleh MC; Argarana CE

来源：Genetica, 1999, 105(3): 233-238.

DOI：10.1023/A:1003817311179

• bacterial insertion sequence
• butanediol dehydrogenase 5 ' UTR
• IS-similar bovine sequence

A sequence similar to prokaryotic transposable elements was identified in the long 5' untranslated region (5'UTR) of the butanediol dehydrogenase cDNA isolated from a bovine brain lambda gt11 library. Several observations suggested that this sequence could be related to bacterial IS elements: (a) 58% nucleotide sequence identity, (b) 56% amino acid sequence identity, and (c) the presence of inverted terminal repeats. However, nucleotide sequence analyses of the 5'UTR bovine cDNA showed the presence of chain-terminating nucleotide substitutions that would render it incapable of encoding a functional transposase. Finally, it was observed that different vertebrate genomes have sequences related to this putative transposable element.

• 出版日期1999