A viral kinase mimics S6 kinase to enhance cell proliferation

作者：Bhatt Aadra Prashant; Wong Jason P; Weinberg Marc S; Host Kurtis M; Giffin Louise C; Buijnink Joshua; van Dijk Evert; Izumiya Yoshihiro; Kung Hsing jien; Temple Brenda R S; Damania Blossom^*

来源：Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(28): 7876-7881.

DOI：10.1073/pnas.1600587113

• cell signaling
• viral protein kinase
• S6K
• KSHV
• ORF36

Viruses depend upon the host cell for manufacturing components of progeny virions. To mitigate the inextricable dependence on host cell protein synthesis, viruses can modulate protein synthesis through a variety of mechanisms. We report that the viral protein kinase (vPK) encoded by open reading frame 36 (ORF36) of Kaposi's sarcoma-associated herpesvirus (KSHV) enhances protein synthesis by mimicking the function of the cellular protein S6 kinase (S6KB1). Similar to S6KB1, vPK phosphorylates the ribosomal S6 protein and up-regulates global protein synthesis. vPK also augments cellular proliferation and anchorage-independent growth. Furthermore, we report that both vPK and S6KB1 phosphorylate the enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) and that both kinases promote endothelial capillary tubule formation.

• 出版日期2016-7-12