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摘要
Objective-To provide values for gastrointestinal permeability and absorptive function tests (GIPFTs) with chromium 51 (Cr-51)-labeled EDTA, lactulose, rhamnose, D-xylose, 3-O-methyl-D-glucose, and sucrose in Beagles and to evaluate potential correlations between markers. %26lt;br%26gt;Animals-19 healthy adult male Beagles. %26lt;br%26gt;Procedures-A test solution containing 3.7 MBq of Cr-51-labeled EDTA, 2 g of lactulose, 2 g of rhamnose, 2 g of D-xylose, 1 g of 3-O-methyl-D-glucose, and 8 g of sucrose was administered intragastrically to each dog. Urinary recovery of each probe was determined 6 hours after administration. %26lt;br%26gt;Results-Mean +/- SD (range) percentage urinary recovery was 6.3 +/- 1.6% (4.3% to 9.7%) for Cr-51-labeled EDTA, 3.3 +/- 1.1% (1.7% to 5.3%) for lactulose, 25.5 +/- 5.0% (16.7% to 36.9%) for rhamnose, and 58.8% +/- 11.0% (40.1% to 87.8%) for 3-O-methyl-D-glucose. Mean (range) recovery ratio was 0.25 +/- 0.06 (0.17 to 0.37) for Cr-51-labeled EDTA to rhamnose, 0.13 +/- 0.04 (0.08 to 0.23) for lactulose to rhamnose, and 0.73 +/- 0.09 (0.60 to 0.90) for D-xylose to 3-O-methyl-D-glucose. Median (range) percentage urinary recovery was 40.3% (31.6% to 62.7%) for o-xylose and 0% (0% to 0.8%) for sucrose. %26lt;br%26gt;Conclusions and Clinical Relevance-Reference values in healthy adult male Beagles for 6 of the most commonly used GIPFT markers were determined. The correlation between results for Cr-51-labeled EDTA and lactulose was not as prominent as that reported for humans and cats; thus, investigators should be cautious in the use and interpretation of GIPFTs performed with sugar probes in dogs with suspected intestinal dysbiosis. (Am J Vet Res 2012;73:654-658)
- 出版日期2012-5
