Unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin

作者：Hajra Saumen^*; Acharyya Susit; Mandal Abhisek; Maity Ramkrishna

来源：Organic and Biomolecular Chemistry, 2017, 15(30): 6401-6410.

DOI：10.1039/c7ob01217a

An expedient synthetic approach has been developed for the unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin. The point of divergence was provided by the lactone aldehyde 6, in which four contiguous stereocenters were achieved by a stereocontrolled Evans syn-aldol reaction of a R-carvone derived enantiopure aldehyde and chiral N-succinyl-oxazolidinone. The lactone aldehyde 6 was synthesized in multigram quantity in three steps. Highly optimized chemo-and stereoselective reactions and functional group interconversion enabled us to assemble (+)-chinensiolide B and (+)-8-epigrosheimin from 6.

• 出版日期2017-8-14
• 单位河北医科大学