Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma

作者：Ma, Hai Qing; Liang, Xiao Ting; Zhao, Jing Jing; Wang, Hui; Sun, Jian Cong; Chen, Yi Bing; Pan, Ke; Xia, Jian Chuan^*

来源：World Journal of Gastroenterology, 2009, 15(38): 4844-4848.

DOI：10.3748/wjg.15.4844

• Neurensin-2
• Hepatocellular carcinoma
• Expression
• Immunohistochemical analysis
• Prognosis

AIM: To investigate the expression of Neurensin-2 (NRSN2) in hepatocellular carcinoma (HCC) and its prognostic values in predicting survival.
METHODS: The expression and prognostic significance of NRSN2 in HCC was examined by performing immunohistochemical analysis using a total of 110 HCC clinical tissue samples, and Western blotting analysis to further confirm the result.
RESULTS: Decreased NRSN2 expression was shown in 70.9% cases. Loss of NRSN2 expression in HCC was significantly related to tumor size (P = 0.006). Larger tumor size was related to negative expression of NRSN2. Patients showing negative NRSN2 expression had a significantly shorter overall survival than those with positive expression (P = 0.008). Multivariate Cox regression analysis indicated that NRSN2 expression level was an independent factor of survival (P = 0.013). Western blotting analysis further confirmed decreased expression of NRSN2 in tumor tissues compared with non-tumorous tissues.
CONCLUSION: Our study indicated that NRSN2 could be a tumor suppressor gene for HCC and a candidate biomarker for long-term survival in HCC.

• 出版日期2009-10-14
• 单位中山大学