A Markov chain description of the stepwise mutation model: Local and global behaviour of the allele process

作者：Caliebe Amke^*; Jochens Arne; Krawczak Michael; Roesler Uwe

来源：Journal of Theoretical Biology, 2010, 266(2): 336-342.

DOI：10.1016/j.jtbi.2010.06.033

• Microsatellite
• Evolution
• Population genetics
• Asymptotic behaviour

The stepwise mutation model (SMM) is a simple, widely used model to describe the evolutionary behaviour of microsatellites. We apply a Markov chain description of the SMM and derive the marginal and joint properties of this process. In addition to the standard SMM, we also consider the normalised allele process. In contrast to the standard process, the normalised process converges to a stationary distribution. We show that the marginal stationary distribution is unimodal. The standard and normalised processes capture the global and the local behaviour of the SMM, respectively.

• 出版日期2010-9-21
• 单位河北医科大学