mTOR Signaling in T Cell Immunity and Autoimmunity

作者：Liu Yu; Zhang Da tong; Liu Xin guang^*

来源：International Reviews of Immunology, 2015, 34(1): 50-66.

DOI：10.3109/08830185.2014.933957

• autoimmunity
• mTOR
• T cell immunity

The mammalian target of rapamycin (mTOR), a phosphoinositide-3-kinase-related protein kinase, acts as a rheostat capable of integrating a variety of environmental cues in the form of nutrients, energy, and growth factors to modulate organismal processes and homeostasis. Recently, there is a growing appreciation of mTOR in adaptive immunity for its crucial roles in keeping a proper balance between T cell quiescence and activation. Under steady-state circumstances, mTOR is subtly inhibited by multiple mechanisms to maintain normal T cell homeostasis. Antigen recognition by naive T cells leads to mTOR activation, which subsequently promotes the differentiation of these cells into distinct effector T cell subsets. This review focuses primarily on the recent literature with respect to the regulatory effects and mechanisms of mTOR signaling in dictating T cell fate, and discusses the therapeutic implications of mTOR modulation in T-cell-mediated autoimmunity.

• 出版日期2015-1
• 单位山东大学