Mathematical modeling of microtubule dynamics Insights into physiology and disease

作者：Buxton Gavin A; Siedlak Sandra L; Perry George; Smith Mark A^*

来源：Progress in Neurobiology, 2010, 92(4): 478-483.

DOI：10.1016/j.pneurobio.2010.08.003

• Cytoskeleton
• Kinetics
• Microtubule
• Model
• Tau phosphorylation

Computer models of microtubule dynamics have provided the basis for many of the theories on the cellular mechanics of the microtubules their polymerization kinetics and the diffusion of tubulin and tau In the three-dimensional model presented here we include the effects of tau concentration and the hydrolysis of GTP-tubulin to GDP-tubulin and observe the emergence of microtubule dynamic instability This Integrated approach simulates the essential physics of microtubule dynamics in a cellular environment The model captures the structure of the microtubules as they undergo steady state dynamic instabilities in this simplified geometry and also yields the average number length and cap size of the microtubules The model achieves realistic geometries and simulates cellular structures found in degenerating neurons in disease states such as Alzheimer disease Further this mo

• 出版日期2010-12