Apple peel bioactive rich extracts effectively inhibit in vitro human LDL cholesterol oxidation

作者：Thilakarathna Surangi H; Rupasinghe H P Vasantha^*; Needs Paul W

来源：Food Chemistry, 2013, 138(1): 463-470.

DOI：10.1016/j.foodchem.2012.09.121

• Low-density lipoprotein cholesterol
• Oxidation
• Quercetin-rich extract
• Triterpene-rich extract
• Physiological concentration
• Quercetin metabolites

Apple peels are rich in antioxidant bioactives and hence can possess the ability to inhibit human low density lipoprotein cholesterol (LDL-C) oxidation. LDL-C oxidation is known to initiate atherosclerotic plaque formation. Unique quercetin-rich (QAE) and triterpene-rich (TAE) apple peel extracts, their constituent compounds and three in vivo quercetin metabolites were investigated for in vitro LDL-C oxidation inhibition. Both extracts effectively inhibited Cu2+-induced LDL-C oxidation. IC50 of QAE and TAE for LDL-C oxidation products were 0.06-8.29 mg/L and 29.58-95.49 mg/L, respectively. Quercetin compounds, chlorogenic acid and phloridzin could contribute more to the effectiveness of QAE at physiological concentrations. The three in vivo quercetin metabolites; quercetin-3%26apos;-sulfate, quercetin-3-glucuronic acid and isorhamnetin-3-glucuronic acid were effective at physiological concentrations and therefore, QAE can be effective in LDL-C oxidation inhibition under physiological conditions. Constituent TAE compounds did not perform well under Cu2+-induction. Overall, both extracts effectively inhibited LDL-C oxidation in vitro.

• 出版日期2013-5-1