A Regioselective Synthesis of 2,5-Diaryl Oxazoles via TsOH/I-2-Mediated Cascade Cyclization

作者：Zhang, Fangdong; Wang, Jing; Zhang, Xueguo; Meng, Xu; Chen, Baohua^*

来源：ChemistrySelect, 2017, 2(28): 8717-8720.

DOI：10.1002/slct.201701390

• Dehydrogenation oxidative cyclization
• Metal-free-catalyzed
• Nitrogen heterocycles
• Special decarboxylation

C A concise and practical approach for synthesis of 2,5-disubstituted oxazole has been developed via a TsOH(p-Methylbenzene sulfonic acid)/I-2-mediated tandem dehydrogenation oxidative cyclization of phenylacetylene and benzylamine. Desired products in high yields have been obtained.

• 出版日期2017-9-29
• 单位兰州大学; 中国科学院; 羰基合成与选择氧化国家重点实验室; 功能有机分子化学国家重点实验室