Al(OTf)(3)-catalyzed one-pot synthesis of pyrrolo[3,2-d]pyrimidinedione derivatives

作者：Ponra Sudipta; Gohain Mukut; Donka Rajashekar; van Tonder Johannes H; Bezuidenhoudt Barend C B^*

来源：Tetrahedron Letters, 2018, 59(30): 2909-2912.

DOI：10.1016/j.tetlet.2018.06.039

• Pyrrolol3,2-dlpyrimidinedione
• Al(OTf)(3)
• Lewis acid catalysis
• Aminopyrimidine
• Propargylic alcohol

A series of polysubstituted pyrrolo[3,2-d]pyrimidinedione derivatives have been synthesized in excellent yields. This prominent scaffold is obtained via an Al(OTf)(3)-catalyzed tandem addition-annulation sequence between propargylic alcohols and aminopyrimidines. The process is simple, facile, inexpensive, and provides a diverse range of substituted pyrrolo [3,2-d]pyrimidinedione derivatives with short reaction times from readily obtainable starting materials.

• 出版日期2018-7-25