Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: A randomised controlled trial

作者：Ried Karin^*; Frank Oliver R; Stocks Nigel P

来源：Maturitas, 2010, 67(2): 144-150.

DOI：10.1016/j.maturitas.2010.06.001

• Cardiovascular health
• Uncontrolled hypertension
• Aged garlic extract
• Complementary medicine

Objective: To assess the effect, tolerability and acceptability of aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with treated, but uncontrolled, hypertension.
Design: A double-blind parallel randomised placebo-controlled trial involving 50 patients whose routine clinical records in general practice documented treated but uncontrolled hypertension. The active treatment group received four capsules of aged garlic extract (960 mg containing 2.4 mg S-allylcysteine) daily for 12 weeks, and the control group received matching placebos. The primary outcome measures were systolic and diastolic blood pressure at baseline, 4,8 and 12 weeks, and change over time. We also assessed tolerability during the trial and acceptability at 12 weeks.
Results: In patients with uncontrolled hypertension (SBP >= 140 mm Hg at baseline), systolic blood pressure was on average 10.2 +/- 4.3 mm Hg (p = 0.03) lower in the garlic group compared with controls over the 12-week treatment period. Changes in blood pressure between the groups were not significant in patients with SBP < 140 mm Hg at baseline. Aged garlic extract was generally well tolerated and acceptability of trial treatment was high (92%).
Conclusion: Our trial suggests that aged garlic extract is superior to placebo in lowering systolic blood pressure similarly to current first line medications in patients with treated but uncontrolled hypertension.

• 出版日期2010-10