Parkinson%26apos;s Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies

作者：Bravo San Pedro Jose M; Gomez Sanchez Ruben; Pizarro Estrella Elisa; Niso Santano Mireia; Gonzalez Polo Rosa A^*; Fuentes Rodriguez Jose M

来源：Parkinson's Disease, 2012, UNSP 151039.

DOI：10.1155/2012/151039

Parkinson%26apos;s disease is the second common neurodegenerative disorder, after Alzheimer%26apos;s disease. It is a clinical syndrome characterized by loss of dopamine-generating cells in the substancia nigra, a region of the midbrain. The etiology of Parkinson%26apos;s disease has long been through to involve both genetic and environmental factors. Mutations in the leucine-rich repeat kinase 2 gene cause late-onset Parkinson%26apos;s disease with a clinical appearance indistinguishable from Parkinson%26apos;s disease idiopathic. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damage proteins and cytoplasmic organelles. This degradative process has been associated with cellular dysfunction in neurodegenerative processes including Parkinson%26apos;s disease. We discuss the role of leucine-rich repeat kinase 2 in autophagy, and how the deregulations of this degradative mechanism in cells can be implicated in the Parkinson%26apos;s disease etiology.

• 出版日期2012