The Nucleotide-binding State of Microtubules Modulates Kinesin Processivity and the Ability of Tau to Inhibit Kinesin-mediated Transport

作者：McVicker Derrick P; Chrin Lynn R; Berger Christopher L^*

来源：JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286(50): 42873-42880.

DOI：10.1074/jbc.M111.292987

Background: Tau inhibits kinesin on GDP-microtubules in vitro, but the physiological significance in neurons is unclear.
Results: On GTP-microtubules, Tau loses its inhibitory effect, and kinesin becomes less processive.
Conclusion: The nucleotide-binding state of the microtubule influences the behavior of both kinesin and Tau.
Significance: Tau has different functions, both inhibitory and non-inhibitory, in regulating axonal transport.

• 出版日期2011-12-16