科研之友
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摘要
H5N1 avian influenza virus replicates aggressively in humans, and the high viral levels sets off an overwhelming inflammatory response. This may explain the infections virulence. Researchers at the Hospital for Tropical Disease in Ho Chi Minh City, Vietnam, studied 18 patients infected with H5N1 influenza and 8 patients with 2 types of human influenza. Those infected with H5N1 virus had much higher levels of virus in the throat compared with those infected with the other viruses. In addition, levels of some inflammatory cytokines and chemokines were correlated with viral load and were highest in the patients who died. One cytokine, interleukin 8, is produced by bronchial epithelial cells and may play a role in acute respiratory distress syndrome. Clinicians should focus on preventing this intense cytokine response by early diagnosis and antiviral treatment.
- 出版日期2006-10-18
