Asymmetric Conjugate Addition of Grignard Reagents to Pyranones

作者：Mao Bin; Fananas Mastral Martin; Feringa Ben L^*

来源：Organic Letters, 2013, 15(2): 286-289.

DOI：10.1021/ol303141x

An efficient enantioselective synthesis of lactones was developed based on the catalytic asymmetric conjugate addition (ACA) of alkyl Grignard reagents to pyranones. The use of 2H-pyran-2-one for the first time in the ACA with Grignard reagents allows for a variety of further transformations to access highly versatile building blocks such as beta-alkyl substituted aldehydes or beta-bromo-gamma-alkyl substituted alcohols with excellent regio- and stereoselectivity.

• 出版日期2013-1-18