Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha 1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

作者：Yamada K; Yazawa K; Shimizu A; Iwanaga T; Hisashi Y; Nuhn M; O'Malley P; Nobori S; Vagefi PA; Patience C; Fishman J; Cooper DKC; Hawley RJ; Greenstein J; Schuurman HJ; Awwad M; Sykes M; Sachs DH^*

来源：Nature Medicine, 2005, 11(1): 32-34.

DOI：10.1038/nm1172

The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.

• 出版日期2005-1