Building bone to reverse osteoporosis and repair fractures

作者：Khosla Sundeep^*; Westendorf Jennifer J; Oursler Merry Jo

来源：Journal of Clinical Investigation, 2008, 118(2): 421-428.

DOI：10.1172/JC133612

An important, unfilled clinical need is the development of new approaches to improve fracture healing and to treat osteoporosis by increasing bone mass. Recombinant forms of bone morphogenetic protein 2 (BMP2) and BMP7 are FDA approved to promote spinal fusion and fracture healing, respectively, and the first FDA-approved anabolic drug for osteoporosis, parathyroid hormone, increases bone mass when administered intermittently but can only be given to patients in the US for two years. As we discuss here, the tremendous explosion over the last two decades in our fundamental understanding of the mechanisms of bone remodeling has led to the prospect of mechanism-based anabolic therapies for bone disorders.

• 出版日期2008-2