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摘要
Objectives: This study aimed to investigate the changes in spontaneous brain activity during orthodontic pain by employing both the amplitude of low-frequency fluctuation (ALFF) and the functional connectivity (FC) analysis of the resting-state functional magnetic resonance imaging (Rs-fMRI). Methods: Seventeen right-handed healthy female volunteers participated in this study. Orthodontic pain was caused by orthodontic separators to the right mandibular first molars. Scanning included the resting state both without orthodontic pain and with orthodontic pain after 24 hours. The blood-oxygenation-level-dependent (BOLD) signal was acquired for calculating the ALFF, and functional connectivity analyses based on regions of interest (ROIs) were performed so as to obtain measures of functional connectivity. Results: During the resting state of orthodontic pain, regions with an increased ALFF included the left insula and the right supplementary motor area. In contrast, the decreased ALFF brain areas contained the bilateral cerebellum posterior lobe, angular gyrus, and superior frontal gyrus. Based on the ALFFs results, we extracted the altered ROIs with ALFF alterations, and the connectivities between the ROIs and the rest brain regions were calculated. The altered FC was mainly located in the pyramis of the bilateral cerebellum, left middle temporal gyrus, cuneus occipital lobe, and left parietal lobe. Conclusions: The results indicated that orthodontic pain could induce ALFF changes in multiple functional brain regions. Meanwhile, the altered functional connectivity between brain regions suggested the interaction of pain and emotional interaction that could be used to explain clinical expression during orthodontic treatment.
- 出版日期2015-11
- 单位四川大学
