Anomalous behavior of pentacoordinate copper complexes of dimethylphenanthroline and derivatives of terpyridine ligands: Studies on DNA binding, cleavage and apoptotic activity

作者：Rajalakshmi Subramaniyam; Weyhermueller Thomas; Freddy Allen J; Vasanthi Hannah R; Nair Balachandran Unni^*

来源：European Journal of Medicinal Chemistry, 2011, 46(2): 608-617.

DOI：10.1016/j.ejmech.2010.11.041

• Copper complexes
• DNA binding
• Groove binder
• DNA cleavage
• Cytotoxicity
• Apoptosis

Copper(II) complexes with substituted terpyridine ligands, namely [Cu(itpy)(dmp)](NO3)(2) (1) and [Cu (PtPY)(dmP)](NO3)(2) (2) have been synthesized and characterized. The interaction of the complexes with CT-DNA has been explored using spectroscopic techniques and viscosity. Complexes 1 and 2 bind in the grooves of DNA, interestingly 1 in the minor and 2 in the major groove. Both the complexes have been found to promote DNA cleavage: complex 1 through hydrolytic and 2 oxidative. Complexes 1 and 2 have been found to be cytotoxic and bring about apoptosis of human lung cancer cell line A549.

• 出版日期2011-2