Phytoquinoids and Secoprezizaane-Type Sesquiterpenes from Illicium arborescens

作者：Chang, Jiun Yang; Abd El Razek, Mohamed H; Chen, Yu Hui; Cheng, Yuan Bin; Chen, Shun Ying; Chien, Ching Te; Kuo, Yao Haur; Shen, Ya Ching^*

来源：Helvetica Chimica Acta, 2010, 93(1): 123-132.

DOI：10.1002/hlca.200900133

A phytochemical investigation of the MeOH extract of Illicium arborescens yielded the two new phytoquinoid epimers, 2,3-didehydro-5-O-methyl-11-epiillifunone E (1) and 2,3-didehydro-5-O-methylillifunone E (2), as well as five new sesquiterpene lactones (8,9-secoprezizaane-type sesquiterpenes). Two of them, i.e., 3 and 4, were minwanensin-type sesquiterpenes, the other two, i.e., 5 and 6, had the anisatin-type (or floridanolide type) skeleton, and the fifth, i.e., 7, was a dunnianin-type sesquiterpene. Their structures were established by analyses of 1D- and 2D-NMR, HR-MS, and chemical evidence. The it? vitro cytotoxic activity of compounds 1-7 was tested against four human tumor cell lines, including HeLa (cervical epitheloid), WiDr (colon), Daoy (medulloblastoma), and Hep2 (liver carcinoma) human-tumor cells.

• 出版日期2010
• 单位中山大学