American Tegumentary Leishmaniasis and HIV-AIDS Association in a Tertiary Care Center in the Brazilian Amazon

作者：Guerra Jorge Augusto O^*; Coelho Leila I R C; Pereira Flavio R; Siqueira Andre M; Ribeiro Rogerio L; Almeida Thiago Miranda L; Lacerda Marcus Vinicius G; Barbosa Maria das Gracas V; Talhari Sinesio

来源：The American Journal of Tropical Medicine and Hygiene, 2011, 85(3): 524-527.

DOI：10.4269/ajtmh.2011.11-0075

American tegumentary leishmaniasis (ATL) and human immunodeficiency virus (HIV) are both common infectious diseases in the Brazilian Amazon with overlapping expansion areas, which leads to the occurrence of Leishmania/HIV coinfection. Most ATL/HIV-acquired immunodeficiency syndrome (AIDS) association cases have been reported from areas where Leishmania (Viannia) braziliensis is the main pathogen; this finding is in contrast with the Amazon region, where L. (V) guyanensis is the most implicated agent, implying distinct clinical and therapeutic aspects. We describe 15 cases of ATL/HIV coinfection treated in a tertiary care center in the Brazilian Amazon between 1999 and 2008. Thirteen patients presented with diverse clinical manifestations of cutaneous leishmaniasis, and four of them had disseminated forms; two patients presented with mucosal leishmaniasis (ML). Seven patients required more than one course of treatment. The particularities of ATL/HIV-AIDS association in L. (V) guyanensis-endemic areas require efforts for an increased understanding of its burden and subsequent improvements in case management.

• 出版日期2011-9