A Prospective Multi-Center Observational Study of Children Hospitalized with Diarrhea in Ho Chi Minh City, Vietnam

作者：Thompson Corinne N; Phan My V T; Nguyen Van Minh Hoang; Pham Van Minh; Nguyen Thanh Vinh; Cao Thu Thuy; Tran Thi Thu Nga; Rabaa Maia A; Pham Thanh Duy; Tran Thi Ngoc Dung; Voong Vinh Phat; Tran Vu Thieu Nga; Le Thi Phuong Tu; Ha Thanh Tuyen; Yoshihara Keisuke; Jenkins Claire; Vu Thuy Duong; Hoang Le Phuc; Pham Thi Ngoc Tuyet; Nguyen Minh Ngoc; Ha Vinh; Nguyen Tran Chinh; Tang Chi Thuong; Ha Manh Tuan; Tran Tinh Hien; Campbell James I; Nguyen Van Vinh Chau; Thwaites Guy

来源：The American Journal of Tropical Medicine and Hygiene, 2015, 92(5): 1045-1052.

DOI：10.4269/ajtmh.14-0655

We performed a prospective multicenter study to address the lack of data on the etiology, clinical and demographic features of hospitalized pediatric diarrhea in Ho Chi Minh City (HCMC), Vietnam. Over 2,000 (1,419 symptomatic and 609 non-diarrheal control) children were enrolled in three hospitals over a 1-year period in 2009-2010. Aiming to detect a panel of pathogens, we identified a known diarrheal pathogen in stool samples from 1,067/1,419 (75.2%) children with diarrhea and from 81/609 (13.3%) children without diarrhea. Rotavirus predominated in the symptomatic children (664/1,419; 46.8%), followed by norovirus (293/1,419; 20.6%). The bacterial pathogens Salmonella, Campylobacter, and Shigella were cumulatively isolated from 204/1,419(14.4%) diarrheal children and exhibited extensive antimicrobial resistance, most notably to fluoroquinolones and third-generation cephalosporins. We suggest renewed efforts in generation and implementation of policies to control the sale and prescription of antimicrobials to curb bacterial resistance and advise consideration of a subsidized rotavirus vaccination policy to limit the morbidity due to diarrheal disease in Vietnam.

• 出版日期2015-5