A suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst

作者：Romanelli Gustavo P^*; Ruiz Diego M; Autino Juan C; Giaccio Hector E

来源：Molecular Diversity, 2010, 14(4): 803-807.

DOI：10.1007/s11030-009-9173-5

• Heterogeneous catalysis
• Preyssler heteropolyacid
• Pictet-Spengler reaction
• N-sulfonyl-1,2,3,4-tetrahydroisoquinoliness
• N-sulfonyl-2,3,4,5-tetrahydro-1H-2-benzazepine
• N-sulfonyl-1,2,3,4,5,6-hexahydrobenzazocine

The preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines, N-sulfonyl-2,3,4,5-tetrahydro-1H-2-benzazepines and N-sulfonyl-1,2,3,4,5,6-hexahydrobenzazocine was catalyzed by a Preyssler heteropolyacid, H(14)[NaP(5)W(30)O(110)], (PA), supported on silica (PASiO(2)40) with excellent yields by means of the Pictet-Spengler reaction of N-aralkylsulfonamides with s-trioxane. The reactions proceed with 0.5 mol% of silica-supported catalyst in toluene at 70A degrees C. The catalyst can be recycled without appreciable loss of the catalytic activity.

• 出版日期2010-11