ABSENCE OF SIMIAN VIRUS 40, BK, AND JC POLYOMAVIRUS, DNA IN SQUAMOUS CELL CARCINOMA LIMITED TO THE ORAL CAVITY

作者：Palmieri Annalisa; Carinci Francesco; Martinelli Marcella; Spinelli Giuseppe; Lo Muzio Lorenzo; Rubini Corrado; Scapoli Luca^*

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2010, 32(3): 375-380.

DOI：10.1002/hed.21197

• squamous cell carcinoma
• human polyomavirus
• SV40
• BKV
• JCV

Background. Head and neck squamous cell carcinomas (SCCs) are among the most aggressive types of cancer. The Simian virus 40 1 which is a polyomavirus known for its oncogenic potential, was found as a contaminant of oral vaccines and has been related to human pleomorphic adenoma in the parotid gland. The aim of this study was to evaluate the presence of SV40 and 2 human polyomaviruses-BK virus (BKV) and JC virus (JCV)-in a large sample of SCCs of the oral cavity.
Methods. Quantitative real-time polymerase chain reaction (PCR) was used to evaluate virus load.
Results. Overall, the prevalence of SV40, BKV, and JCV in oral SCC was negligible, Matched-pair case-control analysis indicated that prevalence among the controls did not significantly differ with respect to analyzed cases.
Conclusion. The results did not indicate a major role for SV40, BKV, and JCV in the etiology of oral SCC.

• 出版日期2010-3
• 单位香港理工大学