Molecular structure and biological function of proliferating cell nuclear antigen

作者：Song Nanmeng; Sang Jianli; Xu Heng^*

来源：Progress in Natural Science, 2007, 17(10): 1127-1135.

• PCNA
• function switch
• PCNA binding motif
• cell cycle
• DNA replication
• DNA repair

Proliferating cell nuclear antigen (PCNA) is the core component of replication complex in eukaryote. As a processive factor of DNA polymerase delta, PCNA coordinates the replication process by interacting with various replication proteins. PCNA appears to play an essential role in many cell events, such as DNA damage repair, cell cycle regulation, and apoptosis, through the coordination or organization of different partners. PCNA is an essential factor in cell proliferation, and has clinical significance in tumor research. In this article we review the functional structure of PCNA, which acts as a function switch in different cell events.

• 出版日期2007-10
• 单位北京师范大学