MARCH-IX mediates ubiquitination and downregulation of ICAM-1

作者：Hoer Simon; Smith Lorraine; Lehner Paul J^*

来源：FEBS Letters, 2007, 581(1): 45-51.

DOI：10.1016/j.febslet.2006.11.075

• MARCH-IX
• ICAM-1
• E3 ubiquitin ligase
• RING-CH
• RING E3 ligase
• transmembrane E3 ligase

The membrane associated RING-CH (MARCH) family of genes encode a novel group of RING-type ubiquitin E3 ligases. Overexpression of one of these family members, MARCH-IX, leads to a downregulation of cell surface major histocompatibility complex (MHC) class I and CD4. Here, we identify MARCH-IX as the first ubiquitin E3 ligase to control expression of the critical cell adhesion molecule ICAM-1. MARCH-IX expression causes ubiquitination and downregulation of ICAM-1 and a short alternative transcript of MARCH-IX lacking the RING-CH domain, termed MARCH-IX RINGless, is shown to act as a positive regulator of MARCH-IX activity.

• 出版日期2007-1-9
• 单位河北医科大学