Molecular epidemiology of Japanese encephalitis virus circulating in South Korea, 1983-2005

作者：Yun Seok Min; Cho Jung Eun; Ju Young Ran; Kim Su Yeon; Ryou Jungsang; Han Myung Guk; Choi Woo Young; Jeong Young Eui^*

来源：Virology Journal, 2010, 7(1): 127.

DOI：10.1186/1743-422X-7-127

We sequenced the envelope (E) gene of 17 strains of the Japanese encephalitis virus (JEV) isolated in South Korea in 1983-2005 and compared the sequences with those from previously reported strains. Our results show the remarkable genetic stability of the E gene sequence in Korean JEV strains. Five pairs of E gene sequences from 10 Korean strains were identical, despite geographical differences and a maximum five-year time span. Sequence comparisons with other Asian strains revealed that the Korean strains are closely related to those from China, Japan, and Vietnam. Genotype 3 strains were predominant in Korea before 1993, when genotype 1 strain K93A07 was first isolated. The two genotypes were detected simultaneously in 1994 but since then, only genotype 1 has been isolated in South Korea. Thus, the genotype change occurred according to the year of isolation rather than the geographical origin.

• 出版日期2010-6-14