A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013-2015 in Catalonia, Spain

作者：Godoy Cristina; Peremiquel Trillas Paula; Andres Cristina; Gimferrer Laura; Maria Uriona Sonia; Gema Codina Maria; Armadans Lluis; del Carmen Martin Maria; Fuentes Francisco; Esperalba Juliana; Campins Magda; Pumarola Tomas; Anton Andres^*

来源：Diagnostic Microbiology and Infectious Disease, 2016, 86(2): 153-159.

DOI：10.1016/j.diagmicrobio.2016.07.023

• Human parainfluenza virus type 3
• HPIV-3
• Immunocompromised
• Children
• Haemagglutinin-neuraminidase
• Fusion protein
• Molecular characterization
• Phylogenetic analysis

Human parainfluenza virus type 3 (HPIV-3) is one of the most common respiratory viruses particularly among young children and immunocompromised patients. The seasonality, prevalence and genetic diversity of HPIV-3 at a Spanish tertiary-hospital from 2013 to 2015 are reported. HPIV-3 infection was laboratory confirmed in 102 patients (76%, under 5 years of age). Among <5 years-old patients, 9 (11.5%) were under any degree of immunosuppression, whereas this percentage was significantly higher (19; 79.2%) among patients older than 5 years. HPIV-3 was detected at varying levels, but mainly during spring and summer. All characterized HN/F sequences fell within C1b, C5 and in other two closely C3a-related groups. Furthermore, a new genetic lineage (C1c) was described. Genetic similarity and epidemiological data confirmed some nosocomial infections, highlighting the importance of the HPIV-3 surveillance, particularly in high-risk patients. This study provides valuable information on HPIV-3 diversity due to the scarce information in Europe.

• 出版日期2016-10