科研之友
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摘要
Rapid, sensitive, cost effective and reproducible stability-indicating derivative spectrophotometric methods have been developed for the estimation of dronedarone HCl employing peak-zero (P-0) and peak-peak (P-P) techniques, and their stability-indicating potential assessed in forced degraded solutions of the drug. The methods were validated with respect to linearity, accuracy, precision and robustness. Excellent linearity was observed in concentrations 2-40 mu g/ml (r (2) = 0.9986). LOD and LOQ values for the proposed methods ranged from 0.42-0.46 mu g/ml and 1.21-1.27 mu g/ml, respectively, and excellent recovery of the drug was obtained in the tablet samples (99.70 +/- 0.84%).
- 出版日期2016-5
