Unusual five amino acid insert within subtype C HIV-1 envelope contributes to dual-tropism (X4R5)

作者：White Elizabeth Johnston^*; McColgan Bryan; Kassaye Seble; Zijenah Lynn; Katzenstein David

来源：AIDS, 2010, 24(7): 1063-1064.

DOI：10.1097/QAD.0b013e328331f717

During the course of HIV infection, some HIV-1 viruses switch from using the CCR5 (R5) coreceptor to using CXCR4 (X4). Here, we describe two subtype C isolates from a Zimbabwean patient that switched from using R5 to using both R5 and X4 with an accompanying addition of five amino acids to the V3 loop region of envelope. The insert appears to be derived from the human genome rather than a duplication within HIV-1.

• 出版日期2010-4-24