Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis

作者：Du, Yue; Huang, Yuhong; Gao, Yue; Song, Bo; Mao, Jun; Chen, Lina; Bai, Lulu; Tang, Jianwu^*

来源：Biomedicine & Pharmacotherapy, 2015, 74: 30-34.

DOI：10.1016/j.biopha.2015.06.005

• Annexin A7
• BAG4
• Apoptosis

Annexin A7 caused an anti-apoptosis phenotype in mouse hepatocarcinoma cells. Yet, the underlying mechanism remains unclear. In this study, we found that Annexin A7 had an inhibitory effect on the mitochondrial Cytochrome C release and Caspase-3 cleavage. Furthermore, Annexin A7 was identified to form a complex with BAG4 which is a negative regulator of apoptosis. Moreover, Annexin A7 was positively correlated with the protein levels of BAG4, Hsp70 and Bcl-2. Both Hsp70 and Bcl-2 bind BAG4 and inhibit Cytochrom C dependent activation of Caspase-3. Taken together, our study indicated Annexin A7 modulated BAG4 and BAG4-binding proteins in mitochondrial apoptosis.

• 出版日期2015-8
• 单位大连医科大学