A Review of the Association between Osteosarcoma Metastasis and Protein Translation

作者：O**orne T S; Khanna C^*

来源：Journal of Comparative Pathology, 2012, 146(2-3): 132-142.

DOI：10.1016/j.jcpa.2011.12.007

• dog
• metastasis
• osteosarcoma
• protein translation

The malignant transformation of mesenchymal cells within the bone leads to the development of osteosarcoma (OS), but the genetic underpinnings of these events are not understood. From a clinical perspective, primary tumour management can be achieved successfully in most patients. However, the development of metastasis to the lungs represents the most common cause of death in OS patients. A clearer understanding of metastasis biology is required to improve cancer mortality and improve outcomes. Modelling the genetics, biology and therapy of OS can be accomplished through research involving a number of species. Most notable is the naturally occurring form of OS that develops in dogs. Through a cross-species and comparative approach important questions can be asked within specific and suitable models to advance our understanding of this disease and its common metastatic outcome. A comparative perspective on the problem of OS metastasis that utilizes a cross-species approach may offer unique opportunities to assist in this prioritization and generate new hypotheses related to this important clinical problem.

• 出版日期2012-4