Limited airway effects in mild asthmatics after exposure to air pollution in a road tunnel

作者：Larsson Britt Marie^*; Grunewald Johan; Skold C Magnus; Lundin Anders; Sandstrom Thomas; Eklund Anders; Svartengren Magnus

来源：Respiratory Medicine, 2010, 104(12): 1912-1918.

DOI：10.1016/j.rmed.2010.06.014

• Air pollution
• Airway inflammation
• Asthmatics
• Bronchial responsiveness

Ambient air pollution is a contributing factor to respiratory morbidity and mortality and asthmatics are a particularly vulnerable population The aim of the study was to investigate whether acute exposure to traffic related air pollution in a road tunnel would increase bronchial responsiveness in mild asthmatics, and if this would be accompanied by increased measures of inflammatory markers in the airways assessed by nasal lavage (NAL) and induced sputum
Fourteen mild asthmatics (7 treated with inhaled corticosteroids) were exposed for 2 h in a road tunnel and a control environment, respectively, separated by at least 3 weeks Symptoms and peak expiratory flow (PEF) were recorded Seven hours following exposure sessions, subjects underwent measurements of fraction of exhaled nitric oxide (FENO), spirometry, and a bronchial provocation test NAL, induced sputum and blood samples were collected
The median PM2 5 and PM10 levels during the exposure occasions in the road tunnel were 80 (range 41-93) mu g/m(3) and 183 (72-213) mu g/m(3) respectively Irritative symptoms from the airways increased and PEF decreased after road tunnel exposure Increased levels of IL 10, IL 12 and TNF alpha were observed in NAL fluid from subjects without ongoing inhaled corn costeroid treatment Forced expiratory volume in 1 s (FEV1) and the degree of bronchial responsiveness in asthmatics did not change significantly after tunnel exposure
We conclude that asthmatics exhibit increased symptoms decreased PEF and signs of inflammator

• 出版日期2010-12