科研之友
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摘要
A mathematical model proposed by Grubelnk et al. [Biophys. Chem. 94 (2001) 59] is employed to study the physiological role of mitochondria and the cytosolic proteins in generating complex Ca2+ oscillations. Intracellular bursting calcium oscillations of point-point, point-cycle and two-folded limit cycle types are observed and explanations are given based on the fast/slow dynamical analysis, especially for point-cycle and two-folded limit cycle types, which have not been reported before. Furthermore, synchronization of coupled bursters of Ca2+ oscillations via gap junctions and the effect of bursting types on synchronization of coupled cells are studied. It is argued that bursting oscillations of point-point type may be superior to achieve synchronization than that of point-cycle type.
