Antiviral evaluation of N-amino-1,2,3-triazoles against Cantagalo virus replication in cell culture

作者：Jordao Alessandro K; Afonso Priscila P; Ferreira Vitor F; de Souza Maria C B V; Almeida Maria C B; Beltrame Cristiana O; Paiva Daniel P; Wardell Solange M S V; Wardell James L; Tiekink Edward R T; Damaso Clarissa R; Cunha Anna C^*

来源：European Journal of Medicinal Chemistry, 2009, 44(9): 3777-3783.

DOI：10.1016/j.ejmech.2009.04.046

• 1,2,3-Triazole derivatives
• Diazo compounds
• Cantagalo virus
• Anti-poxvirus agents
• Molecular structure
• X-ray crystallography

This paper describes the antiviral evaluation of new N-amino-1,2,3-triazole derivatives, 1-(substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl esters, 3 and 1-(4-substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazides, 4, on Cantagalo virus replication. 1-(4-Fluoro-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazide, 4e, exhibited a significant antiviral effect. Characterization of all compounds was confirmed by IR, (1)H and (13)C spectroscopies and elemental analysis. In addition, molecular structure of 4e was also reported.

• 出版日期2009-9