Development of Microwave-Assisted Reactions for PAMAM Dendrimer Synthesis

作者：Lopez Andarias Javier; Guerra Javier^*; Castaneda Gregorio; Merino Sonia; Cena Valentin; Sanchez Verdu Prado

来源：European Journal of Organic Chemistry, 2012, (12): 2331-2337.

DOI：10.1002/ejoc.201101717

• Dendrimers
• Synthetic meth-ods
• Materials science
• Microwave chem-istry

PAMAM dendrimers up to G1 have been synthesized by the divergent method taking advantage of microwave irradiation and using the CoolMateTM accessory to avoid high temperatures and long reaction times, which usually lead to defects in the dendrimer structure. Two tools have been successfully used to determine the purity of the products in addition to NMR spectroscopy, namely MALDI-TOF mass spectrometry and capillary-zone electrophoresis. These techniques show that the dendrimers were obtained in good yields, high purity, and with near-perfect regioselectivity.

• 出版日期2012-4