科研之友
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摘要
A cluster of human histone genes was found on three overlapping clones isolated from cosmid and bacteriophage libraries. These three overlapping segments of the human genome comprise genes coding for H3.1, an H2A pseudogene, and an H2B.1 gene downstream of the previously characterized H1.2 gene. The cosmid clone covers 30 kb upstream of the Hl.2 gene and overlaps with two phage clones covering the core histone genes and the pseudogene. The same arrangement of an H3 gene, an H2A pseudogene and an H2B gene downstream of an Hl gene has been described within a mouse histone gene cluster [Yang et al.: J Biol Chem 262:17118-17125, 1987; Gruber et al.: Gene 95:303-304, 1990].
- 出版日期1993-8
