A facile synthesis of aminomethylene bisphosphonates catalyzed by ytterbium perfluorooctanoate under ionic liquid condition

作者：Reddy Mudumala Veera Narayana; Kim Jongsik; Jeong Yeon Tae^*

来源：Journal of Fluorine Chemistry, 2012, 135: 155-158.

DOI：10.1016/j.jfluchem.2011.10.005

• Ytterbium perfluorooctanoate
• 1-Butyl-3-methylimidazolium chloride
• Aminomethylene bisphosphonates
• Diethyl phosphite

Three-component reactions of amines, triethylorthoformate and diethyl phosphite are efficiently catalyzed by ytterbium perfiuorooctanoate [Yb(PFO)(3)] in 1-butyl-3-methylimidazolium chloride ([bmim][Cl]) ionic liquid, giving the corresponding aminomethylene bisphosphonates in good yields. The catalyst can be recovered and reused for several times without any significant loss of activity.

• 出版日期2012-3