Antiretroviral drug resistance mutations in the reverse transcriptase gene of HIV-1 isolates from Northern Indian patients: a follow-up study

作者：Choudhury Shubhasree Dutta; Chaudhury Alok K; Kalra Rajesh; Andrabi Raiees; Wig Naveet; Biswas Ashutosh; Bala Manju; Luthra Kalpana^*

来源：Archives of Virology, 2010, 155(4): 563-569.

DOI：10.1007/s00705-010-0605-4

The viral reverse transcriptase gene was amplified from the plasma of 27 drug-naive and five drug-experienced HIV patients in Northern India. Follow-up samples of naive patients after antiretroviral therapy initiation were collected in six patients at 3 months and three patients at 6 months. Phylogenetic analysis revealed two new recombinant forms, CRF_CH and CRF_CK, and an accessory non-nucleoside reverse transcriptase inhibitor mutation E138A, not previously reported from India. The major DRMs found in two 6-month follow-up samples were absent in their baseline blood samples. This is the first follow-up study to determine anti-retroviral drug resistance mutations in Indian HIV patients.

• 出版日期2010-4
• 单位河北医科大学