Decisional procalcitonin thresholds are not adapted to elderly patients admitted to the emergency room

作者：Chenevier Gobeaux Camille^*; Trabattoni Eloise; Elfassy Yaelle; Picard Camille; Guerin Sylvie; Borderie Didier; Claessens Yann Erick

来源：Biomarkers, 2012, 17(5): 477-481.

DOI：10.3109/1354750X.2012.685953

• Procalcitonin
• reference values
• infection
• elderly
• immune senescence
• emergency medicine

Context: Diagnosis of sepsis in elderly is challenging. %26lt;br%26gt;Objectives: We investigated whether procalcitonin concentrations in elderly differed from values for the general population. %26lt;br%26gt;Methods: Procalcitonin measurement was assessed prospectively in 307 apyretic patients %26gt;= 75 years visiting the emergency department. %26lt;br%26gt;Results: Median age was 86 years [IQR81-90] and 222 (72%) were female. Procalcitonin concentration was 0.057 mu g/L [0.040-0.092]; 99th percentile was 0.661 mu g/L. Patients with procalcitonin concentrations above decisional thresholds had lower glomerular filtration rate and higher C-reactive protein concentrations. %26lt;br%26gt;Conclusions: Baseline procalcitonin levels are increased in elderly. Elevated values are common and associated to low-grade inflammation and lower eGFR.

• 出版日期2012-8