Normalization of plasma growth hormone alleviated malignant ventricular tachycardia in acromegaly

作者：Liu, Zhi-Hao; Li, Kang; Ding, Yan-Sheng; Qiu, Jian-Xing; Meng, Steven Siyao; Momin, Mohetaboer; Liu, Sheng-Cong; Yi, Tie-Ci; Li, Jian-Ping^*

来源：Journal of Geriatric Cardiology, 2018, 15(8): 547-550.

DOI：10.11909/j.issn.1671-5411.2018.08.003

• Acromegaly
• Growth hormone
• IGF-1
• Ventricular tachycardia

<正>Acromegaly is an insidious endocrine disease characterized by chronic elevation of growth hormone (GH) and insulin-like growth factor-1 (IGF-1).[1] Persistent excess secretion of GH and IGF-1 damages both cardiac structure and function, leading to acromegalic cardiomyopathy,which is one of the most common causes of increased mortality in acromegaly and can result in an average of 10-year reduction in life expectancy.[2,3] In patients with acromegaly,approximately 3%have been reported having a unique cardiomyopathy characterized by biventricular hypertrophy,myocardial necrosis, lymphocytic infiltration, interstitial

• 出版日期2018
• 单位北京大学